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riken final art. added layer plus hair_1_16_v2
Origin of stem cells
Hair follicle-nerve network
ECM_atlas2

Exploring the Role of Tissue Microenvironments

The biochemical and mechanical properties of the cellular microenrivonment play a pivotal role in shaping various biological processes, including cellular behaviour, development, physiology and pathology. In our laboratory, guided by the concept that 'environment dictates behaviour', we explore how cellular and tissue microenvironments impact the behaviour and fate of cells in the context of organ development and regeneration, using mammalian skin as a model. Our primary focus is on revealing the principles underlying the interactions between tissue stem cells and their extracellular matrix, which instruct these processes. Our ultimate research goal is to define and design the microenvironment to manipulate biological processes from outside the cells.

News & Events

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Posted:

Constructing a Single-Cell Transcriptome Atlas of the Hair Cycle to Decipher Tissue Regeneration Dynamics in Human Skin

Yokota et al. SSRN (2024): https://ssrn.com/abstract=4690956

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Job opportunities:

Research Scientists or Postdoctoral Researchers (BDR-23-057).

研究員を募集しています。発生、再生、幹細胞、ECM等に興味のある方、是非ご連絡ください!

Posted:

Col4a2-eGFP mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis

Wuergezhen et al. bioRxiv (2023). [Paper]

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Multimodal ECM consortium:

Hironobu Fujiwara will lead a 5-year ECM research consortium 'Multimodal ECM (2023-2027)'.

藤原が領域代表を務める学術変革領域研究(A) 「マルチモダルECM」がスタートします。

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Funded:

Kohei Omachi has been selected as a JSPS ACT-X program researcher.

大町紘平さんがJST ACT-X(2023)に採択されました。

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Symposium:

International Symposium on Skin Stem Cell Dynamics, 14-15 May 2023 @ Tokyo

国際シンポジウム「Skin Stem Cell Dynamics」を開催します。2023年5月14-15日、東京大学

Contact

2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

650-0047 神戸市中央区港島南町2-2-3

hironobu.fujiwara[at]riken.jp

Tel: 078-306-3171 (Lab)

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